Invention Grant
- Patent Title: Multimeric bicyclic peptide ligands
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Application No.: US17080021Application Date: 2020-10-26
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Publication No.: US11542304B2Publication Date: 2023-01-03
- Inventor: Liuhong Chen , Rachid Lani , Kevin Mcdonnell , Gemma Mudd , Peter U. Park , Punit Upadhyaya
- Applicant: BicycleTx Limited
- Applicant Address: GB Cambridge
- Assignee: BicycleTx Limited
- Current Assignee: BicycleTx Limited
- Current Assignee Address: GB Cambridge
- Agency: Dechert LLP
- Agent Andrea L. C. Reid; Gang Wang
- Priority: GB1802931 20180223,GB1805848 20180409,GB1818158 20181107
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K7/64 ; C07K2/00 ; A61K47/64 ; A61K47/66 ; A61P35/00 ; C07K17/02 ; A61K47/60 ; C07K17/14 ; A61K47/59 ; C07K14/705 ; A61K47/54

Abstract:
The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders and activators of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.
Public/Granted literature
- US20210101933A1 MULTIMERIC BICYCLIC PEPTIDE LIGANDS Public/Granted day:2021-04-08
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