Invention Grant
- Patent Title: Process for producing outer membrane vesicles
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Application No.: US16768919Application Date: 2018-12-04
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Publication No.: US11542467B2Publication Date: 2023-01-03
- Inventor: Matthias Joannes Hendrikus Gerritzen , Leonardus Aldolfus van der Pol , Michiel Stork
- Applicant: De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport
- Applicant Address: NL The Hague
- Assignee: De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport
- Current Assignee: De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport
- Current Assignee Address: NL The Hague
- Agency: N.V. Nederlandsch Octrooibureau
- Priority: EP17205138 20171204
- International Application: PCT/EP2018/083448 WO 20181204
- International Announcement: WO2019/110569 WO 20190613
- Main IPC: C12N1/20
- IPC: C12N1/20 ; A61K39/02 ; A61K39/09 ; A61K39/108 ; A61K39/00
Abstract:
The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process wherein the spontaneous release of bacterial outer membrane vesicles (OMV) of Gram-negative bacteria is stimulated by application of a dissolved oxygen tension (DOT) that is higher than a physiological DOT. The thus produced OMVs are for use in vaccines. The invention further relates to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
Public/Granted literature
- US20210238540A1 An improved process for producing outer membrane vesicles Public/Granted day:2021-08-05
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