Invention Grant
- Patent Title: Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
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Application No.: US16573389Application Date: 2019-09-17
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Publication No.: US11542493B2Publication Date: 2023-01-03
- Inventor: Stuart H. Orkin , Daniel E. Bauer , Jian Xu
- Applicant: The Children's Medical Center Corporation
- Applicant Address: US MA Boston
- Assignee: The Children's Medical Center Corporation
- Current Assignee: The Children's Medical Center Corporation
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Jeanne Jodoin
- Main IPC: C12N15/63
- IPC: C12N15/63 ; A61K35/28 ; C12N5/078 ; C12N15/12 ; C12N9/16 ; C12N15/01 ; C07K14/47 ; C07K14/805 ; C12N15/10 ; A61K35/12 ; A61K38/46 ; C12N9/22
Abstract:
Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.
Public/Granted literature
- US20200087651A1 TARGETING BCL11A DISTAL REGULATORY ELEMENTS FOR FETAL HEMOGLOBIN REINDUCTION Public/Granted day:2020-03-19
Information query
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