Invention Grant
- Patent Title: Oncolytic adenoviral vector and methods of use
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Application No.: US16797291Application Date: 2020-02-21
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Publication No.: US11542526B2Publication Date: 2023-01-03
- Inventor: David T. Curiel , Osvaldo Podhajcer , Maria Veronica Lopez
- Applicant: Unleash Immuno Oncolytics, Inc.
- Applicant Address: US MO St. Louis
- Assignee: Unleash Immuno Oncolytics, Inc.
- Current Assignee: Unleash Immuno Oncolytics, Inc.
- Current Assignee Address: US MO St. Louis
- Agency: Casimir Jones, S.C.
- Agent Rikki A. Hullinger; Peter J. Schlueter
- Main IPC: C12N15/86
- IPC: C12N15/86 ; A61K39/00 ; A61K48/00 ; A61K45/06 ; A61P35/00 ; C12N7/00 ; C07K14/005 ; A61K35/761
Abstract:
Provided herein is a conditionally-replicating serotype 5 adenovirus or adenoviral vector expressing a mutant E1A protein under control of a promoter that is responsive to hypoxia and inflammation and one or more immune modulators under control of a tumor-specific promoter. The adenovirus or adenoviral vector also comprises serotype 3 fiber and hexon proteins. Also provided is a method of inducing cytotoxicity in tumor cells using a composition containing the adenovirus or adenoviral vector.
Public/Granted literature
- US20200270639A1 ONCOLYTIC ADENOVIRAL VECTOR AND METHODS OF USE Public/Granted day:2020-08-27
Information query
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