Invention Grant
- Patent Title: Single nucleotide polymorphism in HLA-B*15:02 and use thereof
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Application No.: US16896336Application Date: 2020-06-09
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Publication No.: US11542556B2Publication Date: 2023-01-03
- Inventor: Hua Fang , Xiequn Xu , Tanya Moreno , Matthew Dedek , Kulvi Kaur
- Applicant: Millennium Health, LLC
- Applicant Address: US CA San Diego
- Assignee: Millennium Health, LLC
- Current Assignee: Millennium Health, LLC
- Current Assignee Address: US CA San Diego
- Agency: Greenberg Traurig, LLP
- Agent Fang Xie
- Main IPC: C12Q1/6883
- IPC: C12Q1/6883 ; A61K31/55
Abstract:
Disclosed herein is a novel single nucleotide polymorphism (SNP) in HLA-B*15:02 that can be used as a biomarker for carbamazepine-induced severe adverse skin reactions in Asians. Also provided herein are methods and reagents for assessing the specific SNP, and applying the SNP in predicting an increased risk of carbamazepine-induced severe adverse skin reactions.
Public/Granted literature
- US20210123102A1 Single Nucleotide Polymorphism in HLA-B*15:02 and Use Thereof Public/Granted day:2021-04-29
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