A motion guide device includes: a supporting body; a movable body which is movable along the supporting body; a roller which is configured to be rollable between the supporting body and the movable body; a roller holding member which is provided on the movable body to hold the roller, wherein the roller holding member comprises an upper roller holding member and a lower roller holding member, a protrusion is formed on the lower roller holding member, the protrusion is in a length direction of the movable body and opposite to a foot of the movable body, an opening is formed on the foot, the opening is opened to a side of the supporting body in the length direction to receive the protrusion, a protrusion width of the protrusion is greater than an opening width of the opening.