Systems, methods, and apparatus related to protecting data stored in volatile memory of a computing system during a standby mode. In one approach, a first signature is generated for data stored in volatile memory. In some cases, the stored data may include sensor data obtained from one or more sensors of a vehicle, mobile device or other electronic device. The first signature is stored in a non-volatile memory device, and then the computing system enters the standby mode. Subsequently, after exiting the standby mode, a second signature is generated for the data stored in the volatile memory. The first signature is read from the non-volatile memory device and compared to the second signature. A signature mismatch indicates that an unintended change has occurred in the stored data during the standby mode. One or more remedial actions are performed by the computing system in response to this signature mismatch.