A method and an apparatus for configuring an uplink time-frequency resource set, and a method and an apparatus for receiving an uplink time-frequency resource set. The configuration method includes: configuring at least one uplink time-frequency resource set for a user configured with an uplink transmission multiplexing mode, wherein the uplink time-frequency resource set includes time-frequency resource units on which the user performs rate matching; and transmitting one or more indication groups to the user to indicate at least one of the uplink time-frequency resource sets, wherein each uplink time-frequency resource set is indicated by at least one of the indication groups.