Invention Grant
- Patent Title: Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and Fragile X syndrome
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Application No.: US16308422Application Date: 2017-06-08
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Publication No.: US11547706B2Publication Date: 2023-01-10
- Inventor: Lauren L. Orefice , David D. Ginty
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2017/036621 WO 20170608
- International Announcement: WO2017/214442 WO 20171214
- Main IPC: A61K31/495
- IPC: A61K31/495 ; A61P25/00 ; A61K31/196 ; A61K31/36 ; A61K31/4196 ; A61K31/437 ; A61K31/4465 ; A61K31/4535 ; C12N15/86 ; A61K9/00 ; A61K45/06
Abstract:
The present invention features a method of reducing tactile dysfunction or anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett Syndrome, or Fragile X syndrome by administering a GABAA agent having reduced blood brain barrier or by expressing a nucleic acid encoding an exogenous alpha or beta subunit of a GABAA receptor in dorsal root ganglion neurons in the subject using a vector.
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