Invention Grant
- Patent Title: Adoptive t-cell therapy
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Application No.: US16314117Application Date: 2017-06-30
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Publication No.: US11547748B2Publication Date: 2023-01-10
- Inventor: Christian Klein , Claudio Sustmann , Gerhard Niederfellner , Martina Geiger , Stefan Endres , Sebastian Kobold
- Applicant: Hoffmann-La Roche Inc. , Ludwig-Maximilians-Universitat Munchen
- Applicant Address: US NJ Little Falls; DE Munich
- Assignee: Hoffmann-La Roche Inc.,Ludwig-Maximilians-Universitat Munchen
- Current Assignee: Hoffmann-La Roche Inc.,Ludwig-Maximilians-Universitat Munchen
- Current Assignee Address: US NJ Little Falls; DE Munich
- Agency: Grimes & Yvon LLP
- Priority: EP16177203 20160630
- International Application: PCT/EP2017/066375 WO 20170630
- International Announcement: WO2018/002358 WO 20180104
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/28 ; C07K16/30 ; C07K14/71 ; C12N5/0783 ; A61P35/00 ; A61K39/395

Abstract:
The present invention generally relates to T-cells, such as CD8+ T-cells, CD4+ T-cells, CD3+ T-cells, γδ T-cells or natural killer (NK) T-cells, transfected/transduced with a fusion protein which is recruited by the use of trivalent, bispecific antibody molecule which specifically binds to/interacts with the extracellular domain of the fusion protein. More precisely, the present invention relates to a kit comprising the nucleic acid molecules, vectors and/or the fusion proteins of the present invention and the trivalent, bispecific antibody molecules of the present invention. Further aspects of the inventions are expression vectors comprising nucleic acid molecules encoding the fusion proteins as well as the trivalent, bispecific antibody molecules. Further, a process for the production of the trivalent, bispecific antibody molecules of the invention and a medicament/pharmaceutical composition comprising said trivalent, bispecific antibody molecules are described. The invention also provides the use of said trivalent, bispecific antibody molecules in a method for the treatment of particular diseases as well as a pharmaceutical compositions/medicament comprising said trivalent, bispecific antibody molecules, wherein said trivalent, bispecific antibody molecule(s) is (are) to be administered in combination with transduced T-cells comprising the fusion protein of the invention. The invention also provides a method for the treatment of particular diseases.
Public/Granted literature
- US20190216908A1 Adoptive T-Cell Therapy Public/Granted day:2019-07-18
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