Eco-friendly signs such as wood and other natural material signs, and methods of making eco-friendly signs, including selecting a substrate as a base material having a first planar surface and an opposing second planar surface, cutting the substrate to a sign dimension, treating the first planar surface to form a smooth print surface, applying a base layer such as a layer of clear ink to the print surface, and applying a signage layer onto the base layer. The eco-friendly sign may be an ADA compliant sign in which the signage layer is a raised of ink produced using a 3-dimensional printer.