The partition wall for commercial vehicles comprises at least one fixed plate (20) and a sliding door (10) able to slide with respect to said fixed wall (20), predisposed to separate the cockpit of the vehicle from the loading compartment. The sliding door (10) is provided, along the upper edge and along the bottom edge, with a plurality of sliding wheels (11, 12) predisposed to slide respectively on an upper guide (13) and on a lower guide (14) associated with the structure of the vehicle. The sliding wheels (11, 12) have a grooved profile predisposed to be coupled with a corresponding rail (19) of said guides (13, 14) having conjugated profile.