A vehicle skeleton structure includes: a first front pillar portion provided at a first side portion of a vehicle body; a second front pillar portion provided at a second side portion of the vehicle body; a front upper cross portion coupled to upper portions of the first and second front pillar portions; a front lower cross portion coupled to lower portions of the first and second front pillar portions; a first rear pillar portion provided at the first side portion along a rear peripheral edge portion of the door opening portion; a second rear pillar portion provided at the second side portion; a rear upper cross portion coupled to upper portions of the first and second rear pillar portions; and a rear lower cross portion coupled to lower portions of the first and second rear pillar portions.