A tamper-evident bag seal including tabs for separating flaps of the seal along a perforation is provided. The tamper-evident bag seal may be a paper or paperboard panel that folds over the handles of an existing bag and is secured to the sides of the bag. The tamper-evident bag seal includes a fold having perforated sections adjacent centrally located tabs. By pulling the tabs in opposite directions, the perforated sections are compromised, permitting access to bag contents and evidencing tampering of the bag seal.