Invention Grant
- Patent Title: Development of a cofilin inhibitor for the treatment of hemorrhagic brain injury-induced neuroinflammation
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Application No.: US16867100Application Date: 2020-05-05
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Publication No.: US11548850B2Publication Date: 2023-01-10
- Inventor: Saleh Alaqel , Viranga Tillekeratne , Zahoor A. Shah
- Applicant: The University of Toledo
- Applicant Address: US OH Toledo
- Assignee: The University of Toledo
- Current Assignee: The University of Toledo
- Current Assignee Address: US OH Toledo
- Agency: MacMillan, Sobanski & Todd, LLC
- Main IPC: C07C275/26
- IPC: C07C275/26 ; A61P25/28 ; C07F7/18
Abstract:
Compounds and methods for inhibiting cofilin activity or reducing total cofilin, improving motor deficits, attenuating LPS-induced microglial activation and inflammation, reducing microglial migration and proliferation, reducing TNF-α, reducing NF-κB, and improving motor deficits in a subject are described.
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