Invention Grant
- Patent Title: Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof
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Application No.: US17096150Application Date: 2020-11-12
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Publication No.: US11548871B2Publication Date: 2023-01-10
- Inventor: Brian P. Bestvater , Zhimin Du , Julie Farand , Gregory Notte , Barton W. Phillips , Doris T. Tang , Chandrasekar Venkataramani , Peiyuan Wang , Kin S. Yang , Anna Zagorska
- Applicant: Gilead Sciences, Inc.
- Applicant Address: US CA Foster City
- Assignee: Gilead Sciences, Inc.
- Current Assignee: Gilead Sciences, Inc.
- Current Assignee Address: US CA Foster City
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D413/04 ; A61K31/65 ; A61P11/00 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D417/14
Abstract:
The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH).
Public/Granted literature
- US20210171500A1 TRIAZOLE CARBAMATE PYRIDYL SULFONAMIDES AS LPA RECEPTOR ANTAGONISTS AND USES THEREOF Public/Granted day:2021-06-10
Information query
