Invention Grant
- Patent Title: Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection
-
Application No.: US16629882Application Date: 2018-07-11
-
Publication No.: US11548893B2Publication Date: 2023-01-10
- Inventor: Michael Bruno Plewe , Kenneth McCormack , Gregory Henkel , Nadezda V. Sokolova , Eric Brown , Vidyasagar Reddy Gantla
- Applicant: Arisan Therapeutics, Inc.
- Applicant Address: US CA San Diego
- Assignee: Arisan Therapeutics, Inc.
- Current Assignee: Arisan Therapeutics, Inc.
- Current Assignee Address: US CA San Diego
- Agent Karl Neidert
- International Application: PCT/US2018/041715 WO 20180711
- International Announcement: WO2019/018185 WO 20190124
- Main IPC: C07D471/10
- IPC: C07D471/10 ; C07D471/08 ; C07D205/12 ; C07D209/54 ; C07D211/58 ; C07D295/192 ; C07D487/04 ; A61K45/06 ; A61K31/015 ; A61K31/13 ; A61K31/165 ; A61K31/397 ; A61K31/445 ; A61K31/4468 ; A61K31/496 ; A61K31/4965 ; A61K31/53 ; A61K31/7056 ; C07C235/40 ; C07C243/08 ; C07C211/56 ; C07C233/62
Abstract:
The compounds of the invention as shown by general structure I, as shown below, are effective in treating filovirus infections. X is selected from the group consisting of O and H; R1 is selected from (C6 to C10) aryl and (C2 to C9) heteroaryl, and R2 is selected from (C1 to C10) alkyl, (C1 to C10) alkenyl, (C1 to C10) alkynyl, (C3 to C10) cycloalkyl, and (C5 to C10) cycloalkenyl, and NR3aR3b is defined in the specification. These compounds are effective in treating filovirii infections including Ebolavirus and Marburg virus.
Public/Granted literature
- US20210171521A1 ENANTIOMERICALLY PURE ADAMANTANE CARBOXAMIDES FOR THE TREATMENT OF FILOVIRUS INFECTION Public/Granted day:2021-06-10
Information query
