A fastener system for securing a panel to a frame comprises one or more rotating fasteners installed in the perimeter edge of the panel. In operation, one or more cam surfaces of the fastener engage receiving surfaces of a receiver on the frame such that, upon rotation of each fastener, the panel is drawn toward the frame. In some embodiments, the panel is moved in a first direction parallel to the panel and a second direction perpendicular to the panel or in a composite diagonal direction inclined relative to the panel. The fastener system may facilitate compression of seals disposed along the perimeter edge of the panel and between a side of the panel and rabbet ledge of the frame and may further facilitate removal and maintenance of the panel.