A system for cleaning heat exchange tubes includes one or more cleaning robots that are assembled with the tubes. Each cleaning robot includes a housing having an opening extending therethrough for receiving one of the heat exchange tubes, a scraper blade extending into the opening of the housing, the scraper blade having an inner scraping edge that opposes the outer surface of one of the tubes, a wheel coupled with the housing for rolling over the outer surface of the tube, and a motor for driving rotation of the wheel to move the cleaning robot over the outer surface of the tube. The system includes a system controller with one or more microprocessors and one or more software programs for monitoring and controlling operation of the cleaning robots.