This disclosure relates to, among other things, electronic device security systems and methods. Certain embodiments disclosed herein provide for protection of cryptographic keys and/or associated operations using both an operating system security service and a software-based whitebox cryptographic security service executing on a device. Leveraging operating system security services and software-based whitebox cryptographic security services may provide enhanced security when compared to using either service alone to protect cryptographic keys and associated operations. In additional embodiments, server-side cryptographic security solutions may be further used to enhance device security implementations.