Systems and methods for management of a distributed ledger including prescription information are disclosed. An example apparatus includes a processor and a logical data structure to configure a device according to an electronic prescription defining an action for a patient, the electronic prescription organized as record(s) in a distributed ledger and processible by the device to apply the action to the patient. The electronic prescription is to cause the device to at least: configure the device to apply the action to the patient; validate the action for the patient using the distributed ledger; and propagate a record of the action to the distributed ledger.