A method and apparatus for combining UL data with a feedback of DL data in a wireless communication system is provided. A wireless device receives, from a network, information informing whether an application level uplink (UL) data, subsequent to a downlink (DL) data, is expected or not. A wireless device initiates random access procedure. A wireless device receives, from the network, the DL data in the random access procedure. A wireless device transmits a UL signaling including both the application level UL data and a feedback of the DL data based on the information informing that the application level UL data subsequent the DL data is expected.