In some aspects, multi-slot transport block (TB) configurations for communicating data between wireless devices, such as between a base station and a user equipment (UE), in a wireless communication system are described. Some examples of multi-slot configurations enable the communication of large payloads. For example, an application of a wireless device may jointly process data from a large file or other large set of packets. In such examples, the wireless device transmitting the large file may utilize a multi-slot TB including multiple TB segments corresponding to respective slots of a transmission. Similarly, a wireless device receiving the large file may utilize the multi-slot TB configuration for receiving the data.