Invention Grant
- Patent Title: Adeno-associated virus virions with variant capsid and methods of use thereof
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Application No.: US16315032Application Date: 2017-07-27
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Publication No.: US11554180B2Publication Date: 2023-01-17
- Inventor: David V. Schaffer , John G. Flannery , William A. Beltran , Leah C. Byrne , Meike Visel
- Applicant: The Regents of the University of California , The Trustees of the University of Pennsylvania
- Applicant Address: US CA Oakland; US PA Philadelphia
- Assignee: The Regents of the University of California,The Trustees of the University of Pennsylvania
- Current Assignee: The Regents of the University of California,The Trustees of the University of Pennsylvania
- Current Assignee Address: US CA Oakland; US PA Philadelphia
- Agency: Bozicevic, Field & Francis LLP
- Agent Shweta Chandra
- International Application: PCT/US2017/044206 WO 20170727
- International Announcement: WO2018/022905 WO 20180201
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K9/00 ; C12N7/00
Abstract:
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
Public/Granted literature
- US20210283274A1 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF Public/Granted day:2021-09-16
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