A method of enhanced data orchestration (EDO). The method comprises receiving a first message by a mediation application executing on a computer system and analyzing the first message by the mediation application based at least in part on invoking a machine learning (ML) model by the mediation application. The analyzing determines that a feature of the first message is a probable first component of an item of personally identifiable information (PII). The method further comprises receiving a second message by the mediation application, determining by the mediation application that a feature of the second message when combined with the feature of the first message constitutes an item of PII, and treating the first message and the second message in accordance with predefined PII handling protocols by the mediation application.