A system for second lab testing of genetic materials is presented. The system includes a computing device configured to receive a specimen from a human subject and perform a smart test on the specimen. The smart test includes a first lab test configured to generate a first lab test identifying a first disease agent and a second lab test configured to generate a second lab test identifying a second disease agent, wherein identifying the second disease agent includes generating a second lab machine-learning model, training the second lab machine-learning model as a function of a second lab test training set, and outputting, as a function of the second lab machine-learning model, the second lab test result using specimen data as an input. The computing device is further configured to generate a smart test result as a function of the smart test.