The present invention provides an ISOFIX interface structure of a vehicle seat. The ISOFIX interface structure of the vehicle seat comprises a shroud mounting base and two ISOFIX shrouds. Two mounting holes are formed in the shroud mounting base, and the mounting holes are penetrated from front to rear. The two ISOFIX shrouds can correspondingly be inserted into the corresponding mounting holes and can be detachably mounted on the shroud mounting base. According to the ISOFIX interface structure of the vehicle seat, the structure is novel, neat, attractive, and easy to realize. The problem is that conventional ISOFIX interfaces collapse surrounding seat foam when being installed. Here, consistency of the two ISOFIX interfaces on the same vehicle seat is guaranteed, the subsequent installation of a child safety seat is convenient, and the assembly and disassembly efficiency of the child safety seat can be effectively improved.