Invention Grant
- Patent Title: Inducing production of full-length progranulin (GRN) from nucleotides including mutations containing a premature stop codon (PTC)
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Application No.: US16717972Application Date: 2019-12-17
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Publication No.: US11560559B2Publication Date: 2023-01-24
- Inventor: Haining Zhu
- Applicant: University of Kentucky Research Foundation
- Applicant Address: US KY Lexington
- Assignee: University of Kentucky Research Foundation
- Current Assignee: University of Kentucky Research Foundation
- Current Assignee Address: US KY Lexington
- Agency: Stites & Harbison PLLC
- Agent Mandy Wilson Decker
- Main IPC: C12N15/10
- IPC: C12N15/10 ; A61K31/7036
Abstract:
Disclosed herein are methods for inducing production of full-length progranulin (GRN) from a nucleotide encoding a GRN with a premature stop codon (GRN-PTC), comprising exposing the GRN-PTC to an aminoglycoside. Methods for inducing production of full-length progranulin (GRN) from a nucleotide encoding a GRN with a premature stop codon (GRN-PTC), comprising administering gentamicin or G418 is also disclosed.
Information query
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