Invention Grant
- Patent Title: Genetic elements driving circular RNA translation and methods of use
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Application No.: US17696606Application Date: 2022-03-16
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Publication No.: US11560567B2Publication Date: 2023-01-24
- Inventor: Howard Y. Chang , Chun-Kan Chen
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Casimir Jones, S.C.
- Agent Tanya A. Arenson
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/67 ; C12N15/113 ; C12N15/85
Abstract:
Provided herein are recombinant circular RNA (circRNA) molecules comprising an internal ribosome entry site (IRES) operably linked to a protein-coding nucleic acid sequence. The IRES includes at least one RNA secondary structure element; and a sequence region that is complementary to an 18S ribosomal RNA (rRNA). Methods of producing a protein in a cell using the recombinant circRNA molecules are also provided.
Public/Granted literature
- US20220251578A1 GENETIC ELEMENTS DRIVING CIRCULAR RNA TRANSLATION AND METHODS OF USE Public/Granted day:2022-08-11
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