Invention Grant
- Patent Title: Fusion moieties and microbial hosts for protein production
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Application No.: US17251899Application Date: 2019-06-19
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Publication No.: US11560582B2Publication Date: 2023-01-24
- Inventor: Peik Haugen , Miriam Grgic , Jenny Johansson Söderberg
- Applicant: UNIVERSITETET I TROMSØ—NORGES ARKTISKE UNIVERSITET
- Applicant Address: NO Tromsø
- Assignee: UNIVERSITETET I TROMSØ—NORGES ARKTISKE UNIVERSITET
- Current Assignee: UNIVERSITETET I TROMSØ—NORGES ARKTISKE UNIVERSITET
- Current Assignee Address: NO Tromsø
- Agency: Fox Rothschild LLP
- Priority: GB1810016 20180619
- International Application: PCT/EP2019/066291 WO 20190619
- International Announcement: WO2019/243467 WO 20191226
- Main IPC: C12P21/02
- IPC: C12P21/02 ; C12N9/16

Abstract:
The present invention relates to fusion proteins comprising (i) a fusion moiety based on SEQ ID NO:1 and (ii) a protein. Also provided are nucleic acids encoding such fusion proteins and compositions comprising such fusion proteins. The invention also provides a method for increasing the expression level of a protein in a host cell or increasing the level of secretion of a protein from a host cell, said methods employing a fusion moiety in accordance with the invention. The invention further provides a method of producing a protein, said method comprising culturing an Aliivibrio wodanis host cell comprising a heterologous nucleic acid molecule encoding a protein under conditions suitable for the expression of the encoded protein. Certain deposited strains of Aliivibrio wodanis are also provided.
Public/Granted literature
- US20210130865A1 FUSION MOIETIES AND MICROBIAL HOSTS FOR PROTEIN PRODUCTION Public/Granted day:2021-05-06
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