Systems, devices, and methods for determining color ambiguity of images or videos. A system includes a color ambiguity score generator, which analyzes an image and determines a color ambiguity score that quantitively indicates a level of color ambiguity that the image is estimated to cause when viewed by a user having color vision deficiency. A local color ambiguity score is generated to quantitively indicate a level of local color ambiguity between (i) an in-image object and (ii) an in-image foreground of that in-image object. A global color ambiguity score is generated to quantitively indicate a level of global color ambiguity between (I) a first in-image object within the image and (II) a second in-image object within that image. The color ambiguity score generator generates the color ambiguity score by utilizing a formula that uses both (A) the local color ambiguity score and (B) the global color ambiguity score.