A method of driving a display panel that includes first and second display-regions includes: determining maximum luminance data among first data including first red data, first green data, and first blue data for the first display-region, calculating a threshold gray-level based on a luminance gain, a gray-level of the maximum luminance data, and a gamma value for the display panel, selecting a smaller value between the threshold gray-level and a maximum gray-level as a gain determination gray-level, calculating a compensation gain obtained by dividing the gain determination gray-level by the gray-level of the maximum luminance data, generating first compensated data by applying the compensation gain to the first data, displaying a first-image in the first display-region based on the first compensated data, and displaying a second-image in the second display-region based on second data including second red data, second green data, and second blue data for the second display-region.