A bipolar plate with an enhanced fluid flow field design is provided for a fuel cell. The bipolar plate includes an inlet, an outlet, and a flow field having a pattern defining a plurality of microchannels configured to provide fluid communication between the inlet and the outlet. The pattern is designed using an inverse permeability field, and is based on a reaction-diffusion algorithm to model channel spacing, thereby providing a variable pitch microchannel pattern to direct fluid from the inlet to the outlet. In various aspects, the reaction-diffusion algorithm utilize Gray-Scott reaction-diffusion equations, which may be used to obtain an anisotropic microchannel layout. The variable pitch microchannel pattern may include a channel spacing based on effective medium theory.