Invention Grant
- Patent Title: Modified-RNA nanoparticles for induction of RNA interference
-
Application No.: US16851986Application Date: 2020-04-17
-
Publication No.: US11571394B2Publication Date: 2023-02-07
- Inventor: Subba Reddy Palli , Ramesh Kumar Dhandapani
- Applicant: University of Kentucky Research Foundation
- Applicant Address: US KY Lexington
- Assignee: University of Kentucky Research Foundation
- Current Assignee: University of Kentucky Research Foundation
- Current Assignee Address: US KY Lexington
- Agency: Stites & Harbison PLLC
- Agent Mandy Wilson Decker
- Main IPC: A61K9/51
- IPC: A61K9/51 ; A61K31/713
Abstract:
Improved RNA interference (RNAi) efficiency in insects is disclosed herein. In particular, certain embodiments of the presently-disclosed subject matter relate to use of nanoformulations of double-stranded RNA (dsRNA) to limit nuclease degradation of the dsRNA, and enhance cellular update and intracellular transport to improve delivery of the dsRNA to enhance RNAi in insects.
Public/Granted literature
- US20200330395A1 MODIFIED-RNA NANOPARTICLES FOR INDUCTION OF RNA INTERFERENCE Public/Granted day:2020-10-22
Information query
