Invention Grant
- Patent Title: Sideroflexins as mitochondrial serine transporters
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Application No.: US17042875Application Date: 2019-03-26
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Publication No.: US11571441B2Publication Date: 2023-02-07
- Inventor: David M. Sabatini , Nora Kory
- Applicant: Whitehead Institute for Biomedical Research
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- Agency: Morse, Barnes-Brown & Pendleton, P.C.
- Agent Lisa M. Warren, Esq.; Erin E. Bryan, Esq.
- International Application: PCT/US2019/024152 WO 20190326
- International Announcement: WO2019/191148 WO 20191003
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K31/713 ; G01N33/574 ; C12N9/22 ; C12N15/11 ; C12N15/113 ; A61P35/04
Abstract:
In some aspects, the disclosure provides methods for modulating mitochondrial transport of serine in a cell, the methods comprising modulating expression or activity of one or more sideroflexins. In some aspects, methods of identifying agents that modulate sideroflexin expression or activity are provided. In some aspects, methods of treating cancer are provided.
Public/Granted literature
- US20210268015A1 SIDEROFLEXINS AS MITOCHONDRIAL SERINE TRANSPORTERS Public/Granted day:2021-09-02
Information query
