Invention Grant
- Patent Title: Method for efficiently inducing antibody, antibody and detection system for hepatitis virus
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Application No.: US16972367Application Date: 2019-06-06
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Publication No.: US11571473B2Publication Date: 2023-02-07
- Inventor: Hisashi Narimatsu , Kiyohiko Angata , Hiroyuki Kaji , Atsushi Kuno , Takashi Sato , Yasunori Chiba , Akira Togayachi , Hiroki Shimizu , Maki Sogabe , Takanori Wagatsuma , Masashi Mizokami , Masaaki Korenaga , Kazuto Tajiri , Tatsuhiko Ozawa
- Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , UNIVERSITY OF TOYAMA
- Applicant Address: JP Tokyo; JP Toyama
- Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY,UNIVERSITY OF TOYAMA
- Current Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY,UNIVERSITY OF TOYAMA
- Current Assignee Address: JP Tokyo; JP Toyama
- Agency: Oliff PLC
- Priority: JPJP2018-108179 20180606
- International Application: PCT/JP2019/022588 WO 20190606
- International Announcement: WO2019/235584 WO 20191212
- Main IPC: A61K39/29
- IPC: A61K39/29 ; C07K14/005 ; A61P31/20 ; C07K16/08 ; G01N33/576 ; A61K39/00
Abstract:
An examination system that recognizes a glycosylated antigen in Dane particles of hepatitis B virus (HBV) and a neutralizing antibody that recognizes the glycosylated antigen and that exhibits an infection-inhibiting activity. It was elucidated that Dane particles are associated with specific glycan structures, and this enabled the construction of a new detection system for infectious, i.e., nucleic acid-containing, hepatitis B virus particles and the provision of a neutralizing antibody that recognizes a glycosylated antigen and that exhibits an infection-inhibiting activity.
Public/Granted literature
- US20210283246A1 METHOD FOR EFFICIENTLY INDUCING ANTIBODY, ANTIBODY AND DETECTION SYSTEM FOR HEPATITIS VIRUS Public/Granted day:2021-09-16
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