Systems and methods for making a flexo plate, and plates, machines, readers, and computer readable media for use therewith. In the system, a plurality of processing machines, each configured to perform one or more process steps in a workflow, includes a controller, a variable operating parameter controlled by the controller, and a reader configured to read machine-readable indicia on the flexo plate. The machine-readable indicia (e.g. bar code, RFID tag, text) is configured for persistent readability downstream of washing (and cutting) steps, without printing in the printing step. The indicia may embody information including at least a plate identifier and instructions corresponding to the at least one variable operating parameter for each of the processing machines or information corresponding to an address in computer storage where the information resides.