- Patent Title: Method for promoting diversification of antibody variable region
-
Application No.: US16484061Application Date: 2018-02-09
-
Publication No.: US11572402B2Publication Date: 2023-02-07
- Inventor: Keisuke Niikura , Yosuke Kamimura
- Applicant: Chiome Bioscience Inc.
- Applicant Address: JP Tokyo
- Assignee: Chiome Bioscience Inc.
- Current Assignee: Chiome Bioscience Inc.
- Current Assignee Address: JP Tokyo
- Agency: Knobbe, Martens, Olson & Bear LLP
- Priority: JPJP2017-023001 20170210
- International Application: PCT/JP2018/004697 WO 20180209
- International Announcement: WO2018/147432 WO 20180816
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12N5/16
Abstract:
The present invention relates to a method for promoting diversification of variable regions of an antibody. Specifically, the present invention relates to a method for promoting diversification of the amino acid sequences of variable regions of an antibody generated by an avian B cell population, wherein the method comprises suppressing the PI3Kα activity of each avian B cell comprised in the avian B cell population expressing the antibody.
Information query
