Invention Grant
- Patent Title: Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells by episomal plasmid gene transfer
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Application No.: US16620938Application Date: 2018-06-14
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Publication No.: US11572544B2Publication Date: 2023-02-07
- Inventor: George Q. Daley
- Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
- Applicant Address: US MA Boston
- Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
- Current Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Jeanne Jodoin
- International Application: PCT/US2018/037485 WO 20180614
- International Announcement: WO2018/232079 WO 20181220
- Main IPC: A61K35/28
- IPC: A61K35/28 ; C12N5/0789
Abstract:
Embodiments herein relate to in vitro production methods of hematopoietic stem cell (HSC) and hematopoietic stem and progenitor cell (HSPC) that have long-term multilineage hematopoiesis potentials upon in vivo engraftment. The HSC and HSPCs are derived from pluripotent stem cells-derived hemogenic endothelia cells (HE) by non-integrative episomal vectors-based gene transfer.
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