Invention Grant
- Patent Title: Methods for evaluating tumor cell spheroids using 3D microfluidic cell culture device
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Application No.: US16498907Application Date: 2018-03-30
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Publication No.: US11572590B2Publication Date: 2023-02-07
- Inventor: Russell W. Jenkins , David Barbie , Cloud P. Paweletz , Elena Ivanova , Amir Aref
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2018/025390 WO 20180330
- International Announcement: WO2018/183839 WO 20181004
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; G01N33/50 ; C12M3/06 ; C12N1/04 ; C12N9/64 ; C12Q1/6869 ; C12Q1/6881 ; G01N33/58
Abstract:
Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.
Public/Granted literature
- US20210087635A1 METHODS FOR EVALUATING TUMOR CELL SPHEROIDS USING 3D MICROFLUIDIC CELL CULTURE DEVICE Public/Granted day:2021-03-25
Information query
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