Invention Grant
- Patent Title: Non-replicative transduction particles with one or more non-native tail fibers and transduction particle-based reporter systems
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Application No.: US16722724Application Date: 2019-12-20
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Publication No.: US11572595B2Publication Date: 2023-02-07
- Inventor: Kyle C. Cady , Colin Lam , Jeffrey Alexander , Kristina Chu , Barbara Eckert , Dylan Goldman , Patrick Lin , Kalyani Mangipudi , Misha Mehta , Arrash Moghaddasi , Hai Nguyen , Natacha Sorenson
- Applicant: Roche Molecular Systems, Inc.
- Applicant Address: US CA Pleasanton
- Assignee: Roche Molecular Systems, Inc.
- Current Assignee: Roche Molecular Systems, Inc.
- Current Assignee Address: US CA Pleasanton
- Agent David J. Chang
- Main IPC: C12Q1/6897
- IPC: C12Q1/6897 ; C12N1/20 ; C12N15/70 ; C12N15/74 ; C12Q1/14 ; C12Q1/18 ; C12Q1/66 ; C12Q1/689
Abstract:
The present invention relates to compositions comprising and methods of producing genetically engineered bacteriophages, bacteriophage-like particles and non-replicating transduction particles (NRTPs) that contain non-native tail fibers that display altered host specificity and/or reactivity. The present invention also relates to methods of using these bacteriophages and NRTPs for the development of novel diagnostics, therapeutics and/or research reagents for bacteria-related diseases.
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