A quick-release mechanism for fan includes a first lateral cover, a second lateral cover, a latch member, a handle, and a pushing member. The first lateral cover has a slot hole. The latch member extends from the slot hole and has an engaging block and an actuation portion connected to the engaging block. The handle has a first pivot end and a second pivot end pivotally connected to the first lateral cover and the second lateral cover, respectively. The handle is movable between a first position and a second position. The pushing member is disposed at the first pivot end. When the handle is at the first position, the actuation portion moves toward the first lateral cover. When the handle is at the second position, the pushing member pushes the actuation portion to move toward a direction away from the inner surface.