A networked system includes a plurality of endpoint devices that each include a compute device and a display device. A virtual desktop configuration system is coupled to the plurality of the plurality of endpoint devices via a network and is configured to retrieve display device characteristics associated with the display device in at least one of the plurality of endpoint devices, configure virtual desktop display characteristics for a virtual desktop based on the display device characteristics, and transmit virtual desktop images having the virtual desktop display characteristics to the compute device in the at least one of the plurality of endpoint devices to cause that compute device in that endpoint device to display the virtual desktop images on the display device in that endpoint device.