In a general aspect, an optimization problem is solved using a hybrid computing system. A classical processor unit receives a first data structure that represents the optimization problem. The classical processor unit executes a branch-and-bound process on the first data structure to generate values for a first subset of elements of a solution to the optimization problem. A second data structure is generated based on the first data structure and the first subset of elements. The second data structure represents a reduced version of the optimization problem. A quantum processor unit and a classical processor unit are used to execute a quantum approximate optimization algorithm (QAOA) on the second data structure to generate values for a second subset of the elements of the solution to the optimization problem. The first subset and second subset are combined to obtain the solution to the optimization problem.