In a general aspect, a method of protecting a software program against tampering can include: executing, by a processor of a user device, an executable code of the software program, the executable code comprising integrity check code sections; during execution of one of the integrity check code sections of the executable code, computing by the processor an integrity check result applied to a code segment of the executable code; transmitting by the processor to a server a message containing the integrity check result and an identifier of the code segment; and when the integrity check result does not correspond to a reference result for the code segment of a genuine version of the software program, receiving by the processor from the server a signal that prevents an operation of the software program from being executed by the processor.