A method and system are disclosed for performing supervised outcome-driven persona-typing, including receiving a first data set having patient specific data, treatment data, and outcome data for each of a plurality of first patients. Once received, the plurality of first patients are grouped based on the first data set, and a persona for each of patient groups is generated. A second data set may then be received for a second patient including second patient specific data. A comparison is then carried out on the second data set to identify an existing persona, and then associate the second patient with the identified persona. Based on each of the above steps, a patient care plan is then created.