A light emitting diode (LED) display panel is provided. The LED display panel includes a printed circuit board (PCB), a flexible substrate disposed on the PCB, and a pixel array. The flexible substrate has a plurality of holes. The pixel array is formed by a first matrix circuit disposed on the flexible substrate, a second matrix circuit disposed on the PCB, and a plurality of LEDs disposed on the PCB, collectively defining a plurality of pixels. Each of the pixels comprises a corresponding one of the LEDs and pixel circuits formed by the first matrix circuit and the second matrix circuit. A projection of each of the LEDs correspondingly overlaps with a projection of one of the holes on the flexible substrate along an extending direction of the holes. A mosaic LED display panel may be formed by multiple LED display panel butted or tiled together.