Methods, apparatus, systems and articles of manufacture to reduce false positive signature matches due to similar media segments in different reference media assets are disclosed. Example apparatus disclosed herein include a signature matcher to compare monitored media signatures with a library of reference media signatures, the monitored media signatures associated with monitored media, the library of reference media signatures including sequences of reference signatures associated with respective reference media assets. Disclosed example apparatus also include a match information identifier to identify a number of different matched reference media assets associated with ones of the sequences of reference media signatures that match a sequence of matched monitored media signatures. Disclosed example apparatus further include a false positive identifier to, in response to the number of different matched reference media assets satisfying a threshold number, eliminate one or more of the matched reference media assets from being credited to the monitored media.