Technologies for secure device configuration and management include a computing device having an I/O device. A trusted agent of the computing device is trusted by a virtual machine monitor of the computing device. The trusted agent executes an attestation algorithm to generate a first secure attestation for the first I/O device and a second secure attestation for the second I/O device, obtains a peer-to-peer communication key, and forwards the peer-to-peer communication key to the first I/O device and a second I/O device to enable secure peer-to-peer communication between the first I/O device and the second I/O device over a communication link secured by the peer-to-peer communication key. Other embodiments are described and claimed.