Invention Grant
- Patent Title: Pharmaceutical formulations
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Application No.: US16083321Application Date: 2017-03-09
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Publication No.: US11576970B2Publication Date: 2023-02-14
- Inventor: Andrew Jeffrey Yates , James Gregory Clipstone
- Applicant: UCB BIOPHARMA SPRL
- Applicant Address: BE Brussels
- Assignee: UCB BIOPHARMA SPRL
- Current Assignee: UCB BIOPHARMA SPRL
- Current Assignee Address: BE Brussels
- Agency: Marshall, Gerstein & Borun LLP
- Priority: GB1604124 20160310
- International Application: PCT/EP2017/055594 WO 20170309
- International Announcement: WO2017/153541 WO 20170914
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/22 ; A61K9/00 ; A61K47/18 ; A61K9/08 ; A61K47/20 ; A61K47/40 ; A61K39/00

Abstract:
The invention relates to a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine. In addition, it relates to a method for reducing precipitation of an antibody or an antigen-binding fragment thereof in a liquid pharmaceutical formulation through addition of methionine and cyclodextrin. In particular, the liquid pharmaceutical formulations comprises an anti-sclerostin antibody, hydroxypropyl-gamma cyclodextrin and methionine and may be used in the treatment of a bone disorder associated with at least one of low bone formation, low bone mineral density, low bone mineral content, low bone mass, low bone quality and low bone strength, and especially for treating osteoporosis. Furthermore, the invention relates to a method of reducing inflammation at injection site in a mammalian subject comprising administering a therapeutically effective amount of a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine.
Public/Granted literature
- US20190083617A1 PHARMACEUTICAL FORMULATIONS Public/Granted day:2019-03-21
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